Synthesis and in vitro Antibacterial Evaluation of N-(4-methoxy-2-nitrophenyl)--alanine Derivatives

In this study a series of N-(4-methoxy-2-nitrophenyl)-beta-alanine derivatives were prepared, characterized by the NMR and IR spectroscopic and microanalysis techniques and evaluated for their antibacterial potency against Gram-positive Staphylococcus aureus and Listeria monocytogenes bacteria strains as well Gram-negative Escherichia coli and Salmonella enteritidis. The assessment was carried out using the in vitro methodologies. According to the results, the best antibacterial properties were shown by hydrazones with the incorporated thien-2-yl and dimethylaminophenyl fragments. According to the data, almost all compounds except N-alkylated dimethylaminophenyl-having hydrazone are regarded as bactericidal agents for the used bacteria. The obtained data demonstrate that the above-mentioned hydrazones could be further selectively explored for the development of antibacterial candidates targeting Gram-positive and Gram-negative bacteria.