Aporphine Alkaloids and a Naphthoquinone Derivative from the Leaves of Phaeanthus Lucidus Oliv. and Their Α-Glucosidase Inhibitory Activity.

Three previously undescribed aporphine alkaloids, phaeanthuslucidines E-G, one previously undescribed naphthoquinone derivative, phaeanthusnaphthoquinone, and three known compounds were isolated from an EtOAc extract of the leaves of Phaeanthus lucidus Oliv. The structures of all previously undescribed compounds were established through extensive spectroscopic investigations and high-resolution mass spectroscopy. The 6aR configuration of phaeanthuslucidines E-G was assigned by comparing their ECD spectra and specific rotation values with the reported known compounds. Some isolated compounds were evaluated for their alpha-glucosidase inhibitory activity. Among these compounds, phaeanthuslucidine E showed the highest alpha-glucosidase inhibitory activity with an IC50 value of 17.9 +/- 0.4 mu M. The molecular docking of phaeanthuslucidine E was further studied.