Biomimetic 3D composite scaffold with pH-Responsive micropatterns for wound healing

Wound healing, a crucial process for all individuals, is often hindered by limited skin donors, bacterial infections, and imprecise drug delivery. This study demonstrates an innovative biomimetic 3D composite scaffold with pHresponsive micropatterns that replicates the hierarchical biostructure of natural skin through hybrid electrotechnologies. The engineered microstructure not only prevents bacterial infections but also possesses biomimetic physical, chemical, and mechanical properties of natural skin, creating an infiltration gradient to meet the distinct moisture requirements of the epidermis and dermis, while ensuring appropriate water absorption, breathability, and hydrophobicity. Moreover, the composite scaffold triggered by exudate in response to pH changes within the wound enables precise drug release for localized treatment. In vivo assays confirm the biomimetic 3D composite scaffold with pH-responsive micropatterns as a potential skin substitute for expediting wound healing.