Selective synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their N1-substituted analogues via Pd(II)-catalyzed cascade annulation of o-aminobenzoic acids with CO, ammonium acetate and aldehydes

A range of 2,3-dihydroquinazolin-4(1H)-ones and their N1-substituted analogues have been selectively prepared mostly in moderate to excellent yields through Pd(II)-catalyzed one-pot annulation of o-aminobenzoic acids with CO, ammonium acetate and aldehydes. This protocol features with simple raw materials and operation, low catalyst loading and cost, high step economy & efficiency, good product diversity and broad applicability.