Synthesis and thermal safety assessment of methyl (αE)-2-(bromomethyl)-α-(methoxyimino)benzeneacetate

Methyl (αE)-2-(bromomethyl)-α-(methoxyimino)benzeneacetate (MBMA), the key intermediate in the synthesis of Strobilurins fungicides, such as trifloxystrobin, kresoxim-methyl, fenaminstrobin, and dimoxystrobin, pose potential thermal safety risks. The thermal hazards of MBMA were investigated in this study. The thermal safety and decomposition kinetic parameters of MBMA were obtained, and the thermal decomposition mechanism and pyrolysis products of MBMA were analyzed using a combined test in conjunction with density functional theory (DFT), which is significant to understanding the intrinsic safety of MBMA in industry.