Rose Bengal Promoted Catalytic Amyloid- Oxygenation by Sonoactivation

Catalytic photooxygenation of amyloid-13 is a leading therapeutic strategy for the treatment of Alzheimer disease; however, the limited tissue permeability of light hampers its clinical application. We here report an alternative catalytic sonooxygenation strategy to circumvent this problem. Amyloid-13 aggregates were oxygenated by using rose bengal as a sonosensitizer under ultrasound irradiation. Structure-activity relationships revealed that xanthene-derived catalysts containing halogen atoms furnished a superior amyloid oxygenation activity.