Application of the Crystal Structure of the SARS-CoV-2 Spike Protein for the Development of a Peptide Vaccine against Virus

A. S. Ivanovsky, I. A. Kolesnikov,Yu. V. Kordonskaya, A. V. Ermakov, M. A. Marchenkova,V. I. Timofeev,Yu. V. Pisarevsky,Yu. A. Dyakova, M. V. Kovalchuk

CRYSTALLOGRAPHY REPORTS（2023）

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摘要

Based on the spike protein of the SARS-CoV-2 virus, a protein capable of causing an immune answer has been predicted. The protein stability in solution is confirmed by the molecular dynamics simulation. Immunomodulation has shown that this protein causes an immune reaction and, correspondingly, may serve a vaccine prototype.

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