Synthesis of (3-Thienyl)-Substituted 2,2'-Bipyridines and Their Application as Activators of Platinum Electrode Catalytic Activity Towards Cholesterol Electrooxidation

Several new derivatives of 2,2'-bipyridines with a spacer group separated from the 2,2-bipyridine fragment, namely, an ethynyl fragment, were obtained using the Sonagashira cross-coupling reaction. The resulting derivatives were physically adsorbed on platinum electrode and were then used as activators of the catalytic activity of a platinum electrode in the reaction of cholesterol electrooxidation in an acetonitrile medium. Sensitivity, limit of detection and detectable concentration range were calculated, and the best results was established as 6.2 +/- 0.6 mu A/mM, 0.08 mM and 0-0.3 mM, respectively. These results show that the prepared compounds adsorbed on platinum electrode are perspective systems for developing of new enzymeless cholesterol sensor based on them.