Mild SARS-CoV-2 infection with the Omicron variant mimicking metastatic cancer on whole body 18-F FDG PET/CT imaging

Abstract We present a case with unusual findings on nuclear imaging after mild SARS-CoV-2 infection. 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography showed activity in the lower thoracic spinal column, in portal lymph nodes, and in the terminal ileum and surrounding lymph nodes, all suspicious for metastatic cancer. Three months later, the findings had either disappeared or were considered reactive.