Supplementary Figure 3 from Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer

Supplementary Figure S3 demonstrates the expression profiles of signature genes (including lineage, co-stimulation, co-inhibition, cytotoxic molecules, and transcription factors) in GD2-2840z-CARTs, GD2-CARrejTs, and control T cells through a heatmap. It also includes UMAP projections of CITE-seq data highlighting the distribution of CD3, CD4, and CD8 markers, and phenotypic markers specific to GD2-2840z-CARTs and GD2-CARrejTs. Additionally, a heatmap showcases the expression of chemokine receptor-related genes in these cell types, providing insights into their functional characteristics.