Itaconate as a potential target for antimalarial therapy
TRENDS IN PARASITOLOGY(2024)
摘要
In a recent publication, Ramalho et al. investigated monocyte-derived dendritic cell (MODC) mobilization in response to Plasmodium infection. The authors showed that elevated levels of itaconate in MODCs results in reduced CD8 T cell activation and that the absence of itaconate is associated with enhanced parasite control.
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关键词
itaconate,malaria,metabolism,monocyte-derived dendritic cells,mitochondria,PD-L1
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