Association Between Short-Term Exposure to Ambient Air Pollutants and Biomarkers Indicative of Inflammation and Oxidative Stress: a Cross-Sectional Study Using KoGES-HEXA Data

Background: Air pollution -induced systemic inflammation and oxidative stress are hypothesized to be the major biological mechanisms underlying pathological outcomes. We examined the association between short-term exposure to ambient air pollutants and biomarkers of inflammation and oxidative stress in 2199 general middle-aged Korean population residing in metropolitan areas. Methods: Serum levels of inflammatory cytokines (interleukin [IL] -1/3, IL -6, IL -8, IL -10, and tumor necrosis factor [TNF]-a) and urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. Daily concentrations of a series of air pollutants (particulate matter [PM]10, PM2.5, SO2, NO2, CO, and O3) were predicted using the Community Multiscale Air Quality modeling system, and participant -level pollutant exposure was determined using geocoded residential addresses. Short-term exposure was defined as the 1- to 7 -day moving averages. Results: The multivariable-adjusted linear models controlling for the sociodemographic, lifestyle, temporal, and meteorological factors identified positive associations of PM with IL -1/3, IL -8, IL -10, TNF-a, and 8-OHdG levels; SO2 with IL -10 levels, CO with IL -1/3, IL -10, and TNF-a levels; and O3 with IL -1/3, IL -8, and 8-OHdG levels. O3 levels were inversely associated with IL -10 levels. For each pollutant, the strongest associations were observed for the 7 -day average PM and CO with IL -1/3 (per 10-mu g/m3 increase in PM10: 2.7%, 95% confidence interval [CI] = 0.6-4.8; per 10-mu g/m3 increase in PM2.5: 6.4%, 95% CI = 2.4-10.5; per 0.1-ppm increase in CO: 3.3%, 95% CI = 0.3-6.5); the 2 -day average SO2 with IL -10 levels (per 1-ppb increase in SO2: 1.1%, 95% CI = 0.1-2.1); and the 7 -day average O3 with IL -8 levels (per 1-ppb increase in O3: 1.3%, 95% CI = 0.7-1.9). Conclusions: Short-term exposure to ambient air pollutants may induce oxidative damage and pro -inflammatory roles, together with counter -regulatory anti-inflammatory response.