Age-Associated Trajetories of Tongue Coating Microbiota in a Healthy Chinese Community-Dwelling Population

crossref(2024)

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摘要
Abstract To profiled age- and sex-associated continuous and dynamic alterations in the tongue coating (TC) microbiota with advancing age, we collected 2,527 TC from healthy Chinese community-dwelling individuals aged 1–100 years, and completed 16S rDNA V3-V4 region sequencing. We identified 23 age-associated microbial indicators and built a “TC microbiota clock” model that could characterize the advancement of age using random forest regression methods. Most pathogenic indicators showed a gradual increase or decrease first and then increased with age, suggesting a higher risk of digestive and respiratory tract diseases in childhood and old age compared with middle age. Additionally, two phenotypes of TC microbiota in the old highlighted two different networks between the TC microbiota and host’s healthy aging. Our findings suggest that age-related immuno-physiological properties are accompanied by the sex-independent succession of the TC microbiota with age, and TC microbiota as a promising indicator to evaluate an individual’s physiological status.
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