Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs

To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-Helicobacter pylori effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter pylori properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.