Effect of plasmapheresis on drug pharmacokinetics in children: a structured review of the current literature

In this structured review, we present a structured overview on the effect of plasmapheresis on pharmacokinetics (PK) of drugs in children. Furthermore, we intended to analyse if, based on the changed PK, evidence-based drug dosing regimens for drugs at therapeutic dosages in this population have been developed. A structured literature search assessing drug PK/exposure in children undergoing plasmapheresis was conducted in EMBASE and PubMed on 23 March 2023. Studies were labelled as relevant when data on PK/exposure after plasmapheresis in patients younger than 18 years-old was reported. Extracted parameters included patient characteristics, plasmapheresis related characteristics and PK/exposure related parameters. Twenty-six studies were identified, 96