Stereoselective Synthesis of Unsymmetrical 1,1-Diborylalkenes

SYNLETT(2024)

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Abstract
1,1-Diborylalkene, a class of important diboryl species,serves as the synthetic precursor of multisubstituted olefin, which is aprevalent building block in natural products, functional materials, andpharmaceuticals. Current methods mainly afford symmetrical 1,1-dibo-rylalkenes, and late-stage differentiation of the two identical borylgroups is required to achieve selective difunctionalization. In compari-son, stereoselective synthesis of unsymmetrical 1,1-diborylalkenes(UDBA) are less-explored. This Synpacts article provides a brief summa-ry of the achievements in the synthesis of UDBAs. In particularly, wehighlight our recent work on the unsymmetrical 1,1-diborylation ofalkynes using a neutral sp(2)-sp(3) diboron reagent to access UDBAs andtheir controllable stepwise derivatization. 1 Introduction 2 Background: Unsymmetrical 1,1-Diborylalkene Synthesis 3 Stereoselective Unsymmetrical 1,1-Diborylation of Alkynes witha Neutral sp2-sp3 Diboron Reagent 4 Summary and Outlook
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Key words
boron,unsymmetrical 1,1-diborylalkene,diborylation,diboron reagent,stereoselective
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