MP66-10 DEVELOPMENT AND EVALUATION OF A NOVEL PENILE BLOOD OXYGEN SENSOR FOR ASSESSING TISSUE OXYGENATION

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (MP66)1 May 2024MP66-10 DEVELOPMENT AND EVALUATION OF A NOVEL PENILE BLOOD OXYGEN SENSOR FOR ASSESSING TISSUE OXYGENATION Gal Saffati, Anna Wiatrowski, Mohit Khera, and Connor L. Evans Gal SaffatiGal Saffati , Anna WiatrowskiAnna Wiatrowski , Mohit KheraMohit Khera , and Connor L. EvansConnor L. Evans View All Author Informationhttps://doi.org/10.1097/01.JU.0001009468.01097.19.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Penile blood oxygen concentration remains a relatively unexplored parameter. Despite the role of oxygenation in maintaining penile tissue health and function, there is a paucity of research focusing specifically on monitoring this parameter. This knowledge gap hinders our understanding of the physiological and pathophysiological mechanisms underlying penile disorders and limits the development of targeted therapeutic interventions. We aimed to develop and test a novel noninvasive penile blood oxygen sensor that can accurately assess the oxygen concentration in the penis, enabling a deeper exploration of its clinical significance and potential implications in disease management. METHODS: A novel penile blood oxygen sensor was developed for assessing oxygen levels in the penis. The study had ethical approval from the Institutional Review Board (IRB) and included three groups of participants: The study population was categorized into three distinct groups: the first group comprised patients diagnosed with Peyronie's Disease (PD) but without clinical erectile dysfunction (ED), serving as our control group; the second group consisted of patients clinically diagnosed with ED, who utilized the sensor with a band and supplementary adhesive; and the third group included patients who used the sensor without the the supplementary adhesive. The sensor was applied during a doppler penile ultrasound with subsequent intracavernosal injection therapy. RESULTS: A total of 7 patients were included, 3 with PD and 4 with ED. The control group exhibited a spike in penile partial oxygen (pO2) levels after injection, followed by a return to baseline (Figure 1A). Patients with ED showed a gradual decrease in penile oxygen levels during equilibration, a sharp increase after injection, and subsequent decline towards baseline levels within 3-5 minutes of erection (Figure 1B). CONCLUSIONS: The observed temporal sequence of changes in penile oxygenation offers valuable insights into the dynamic physiological responses that occur during distinct stages of the erectile process. These findings contribute to our understanding of the intricate mechanisms underlying penile vascular physiology and their roles in erectile function. An analysis of the full patient cohort is currently ongoing. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1089 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Gal Saffati More articles by this author Anna Wiatrowski More articles by this author Mohit Khera More articles by this author Connor L. Evans More articles by this author Expand All Advertisement PDF downloadLoading ...