Figure S5 from Multiomic-Based Molecular Landscape of FaDu Xenograft Tumors in Mice after a Combinatorial Treatment with Radiation and an HSP90 Inhibitor Identifies Adaptation-Induced Targets of Resistance and Therapeutic Intervention

Supplemental Figure S5. Proteomic and Phospho-proteomic comparison of changes observed comparing UT_Wk1 to UT_Wk2 (A), Treated Week 1 to UT_Wk1 (B) and Treated Week 2 to UT_Wk2 (C). Trends towards significance only. Normalized to intensity. No notable change is shown in white, upregulation is red, downregulation is blue. Supplemental Figure 4A indicates change in UT_Wk2 compared to UT_Wk1, interestingly p53 and PDL-1 protein expression decrease over three days. Supplemental Figure 6A indicates change in Untreated Week 2 compared to Untreated Week 1, interestingly p53 and PDL-1 protein expression show a decreasing trend.