Supplementary Table S1 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies

Supplementary Table S1: The catalytic efficiency (kcat/Km) of MMP cleavage of XTX301. MMPs from 5 different classes, collagenases (MMP1 and MMP8), gelatinases (MMP2 and MMP9), matrilysin (MMP7), stromelysins (MMP10), and membrane-anchored (MMP14) were selected and evaluated for their ability to cleave XTX301 in vitro. The catalytic efficiency (kcat/Km) of the MMP cleavage of XTX301 was determined by incubating XTX301 with activated MMPs. The data points represent the mean of 2 independent experiments analyzed as technical replicates (in duplicate) by CE-SDS.