Highly stereoselective α-glycosylation with GalN₃ donors enabled collective synthesis of mucin-related tumor associated carbohydrates antigens

Kunxiu Shou,Yunqin Zhang, Yujie Ji,Bin Liu, Qingli Zhou, Qiang Tan,Fuying Li,Xiufang Wang,Gang Lu,Guozhi Xiao

Chemical Science（2024）

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摘要

AbstractMucin-related tumor-associated carbohydrate antigens (TACA) are important and interesting targets for cancer vaccine therapy. However, the efficient access to a library of mucin-related TACA remains a challenging task. One of...

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Highly stereoselective α-glycosylation with GalN3 donors enabled collective synthesis of mucin-related tumor associated carbohydrates antigens

Highly stereoselective α-glycosylation with GalN₃ donors enabled collective synthesis of mucin-related tumor associated carbohydrates antigens