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Haploinsufficiency of Phosphodiesterase 10A Activates PI3K/AKT Signaling Independent of PTEN to Induce an Aggressive Glioma Phenotype

Nicholas Nuechterlein,Allison Shelbourn,Frank Szulzewsky,Sonali Arora, Michelle Casad,Siobhan Pattwell,Leyre Merino-Galan,Erik Sulman, Sumaita Arowa,Neriah Alvinez,Miyeon Jung,Desmond Brown,Kayen Tang,Sadhana Jackson,Stefan Stoica, Prashant Chittaboina,Yeshavanth K. Banasavadi-Siddegowda,Hans-Georg Wirsching,Nephi Stella,Linda Shapiro,Patrick Paddison,Anoop P. Patel,Mark R. Gilbert,Zied Abdullaev,Kenneth Aldape,Drew Pratt,Eric C. Holland,Patrick J. Cimino

GENES & DEVELOPMENT（2024）

Cited 0|Views25
Key words
glioblastoma,PDE10A,RCAS/tv-a,PI3K/ATK pathway,mesenchymal cell state
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