PD56-05 URINARY FACTORS INFLUENCING DECISIONS TO PROCEED WITH LIVING KIDNEY DONATION AMONG CANDIDATES WITH KIDNEY STONE DISEASE

You have accessJournal of UrologyTransplantation & Vascular Surgery II (PD56)1 May 2024PD56-05 URINARY FACTORS INFLUENCING DECISIONS TO PROCEED WITH LIVING KIDNEY DONATION AMONG CANDIDATES WITH KIDNEY STONE DISEASE Tyler Compher, Sambhavi Krishnamoorthy, Kyle D. Wood, Shikha Mehta, Michael J. Hanaway, Dean G. Assimos, Vineeta Kumar, Anna L. Zisman, and Joseph J. Crivelli Tyler CompherTyler Compher , Sambhavi KrishnamoorthySambhavi Krishnamoorthy , Kyle D. WoodKyle D. Wood , Shikha MehtaShikha Mehta , Michael J. HanawayMichael J. Hanaway , Dean G. AssimosDean G. Assimos , Vineeta KumarVineeta Kumar , Anna L. ZismanAnna L. Zisman , and Joseph J. CrivelliJoseph J. Crivelli View All Author Informationhttps://doi.org/10.1097/01.JU.0001008928.01012.0d.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Guidelines recommend that patients with a self-reported history of kidney stones or stones found on imaging during living kidney donor evaluation undergo 24-hour urine testing. We report 24-hour urine findings that were associated with the decision to proceed with living kidney donation in candidates with kidney stone disease at two high-volume transplant centers. METHODS: We identified potential living kidney donors with either a self-reported history of kidney stones or stones identified on imaging, all of whom underwent 24-hour urine collection at the University of Alabama at Birmingham (UAB) or the University of Chicago (UC). Patients who couldn't donate due to other medical conditions were excluded. All recommendations and decisions regarding donor candidacy were made by multidisciplinary living donor teams. Statistical analysis was performed using t tests and chi-square tests, or corresponding non-parametric tests when appropriate. RESULTS: A total of 106 kidney donor candidates met study criteria, of whom 22 (21%) were rejected for donation (Table 1). Candidates rejected for donation had significantly higher calcium excretion and supersaturations of calcium oxalate and calcium phosphate. Thirty-four candidates repeated 24-hour urine analyses following dietary or medical interventions for stone prevention (Table 2). Candidates approved for donation had a significant increase in urinary volume and reduction in calcium excretion, oxalate excretion, as well as supersaturations of calcium oxalate, calcium phosphate, and uric acid. Those rejected for donation had no statistically significant changes in urinary parameters. CONCLUSIONS: Several urinary risk factors for kidney stones, as well as improvement in these factors following dietary or medical management were associated with the decision to proceed with living kidney donation. A prospective longitudinal study needs to be undertaken to determine the factors predicting stone recurrence for the donor. Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1203 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Tyler Compher More articles by this author Sambhavi Krishnamoorthy More articles by this author Kyle D. Wood More articles by this author Shikha Mehta More articles by this author Michael J. Hanaway More articles by this author Dean G. Assimos More articles by this author Vineeta Kumar More articles by this author Anna L. Zisman More articles by this author Joseph J. Crivelli More articles by this author Expand All Advertisement PDF downloadLoading ...