Figure 1 from Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging

Colon cancer models have genotypic and phenotypic diversity. A, The alleles in the GEMM used in this study. Cre, Cre recombinase; ER, estrogen receptor; loxP, Cre-loxP recombination site. B, Oncoprint showing the prevalence of genetic alterations of the alleles in A, determined using cBioportal from the Colorectal Adenocarcinoma, TCGA, PanCancer Atlas (n = 524). C, Venn diagrams of the genetic crossing strategies for the GEMM. D, Heatmap illustrating correlation of intestinal cancer GEMM gene expression with patient-derived CMS profiles. E, Gene set enrichment analysis for the GEMM with the Molecular Signatures Database (MSigDB) hallmark gene set. Data were ordered using hierarchal clustering. Extended heatmap is shown in Supplementary Fig. S1. (A, Created with BioRender.com.)