Step-Wise, Tandem One-Pot Syntheses and Antifungal Evaluation of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-arylbenzamides in Water – a Green Protocol

One-pot, eco-friendly, three-component syntheses of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-aryllbenzamides have been developed by combining phthalic anhydride with anilines and anthranilamide in water without any catalyst. The reactions are simple to set up, have excellent yields, and employ water as solvent, making their synthesis an environmentally friendly procedure. All synthesized compounds were tested against fungal strains, and compounds 4c, 4d, 4g, and 4i showed prominent activity.