Cucurbit[7]uril-Catalyzed Beckmann Rearrangement of Arylketoximes.

With the existence of cucurbit[7]uril (Q[7]), a supramolecular catalysis strategy for the Beckmann rearrangement of aryl ketoximes to N-substituted amides was successfully established. The cavity of Q[7] was found to be essential for substrate encapsulation and the rearrangement reaction through comparative experiments and studies on host-guest interactions. This supramolecular strategy provides an efficient route for the rearrangement reaction incorporating a carbonation intermediate.