High efficacy of CD19 CAR T-cells in patients with transformed Waldenström macroglobulinemia.

Eric Durot,Damien Roos-Weil,Adrien Chauchet,Justine Decroocq,Roberta Di Blasi,Thomas Gastinne, Hedi Bensaber,Morgane Cheminant,Caroline Jacquet,Stéphanie Guidez, François-Xavier Gros,Emmanuel Bachy, Arthur Coste,Pascale Cony-Makhoul,Steven P. Treon,Alain Delmer,Ran Reshef, Steven Le Gouill,Jorge J. Castillo,Roch Houot

Blood（2024）

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摘要

Histological transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with CAR T-cells showing a high efficacy and no unexpected toxicity.

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