Selective Hydro- and Deuterodechlorination of Trichloroacetamides under Controlled Electrochemical Conditions to Prepare Mono-, Di-, and Deuterochloroacetamides

Mono- and dichloro acetamides were prepared via a hydrodechlorination reaction of trichloroacetamides under controlled electrochemical conditions. The reactions were carried out in an undivided cell with constant current flow using n-Bu4NI as supporting electrolyte and methanol as solvent and proton source. Deuterodechlorination of trichloroacetamide was also successful when methanol-d4 was used as solvent under identical electrochemical conditions. image