Pf Bacteriophage Inhibits Neutrophil Migration in the Lung
biorxiv(2022)
摘要
Bacteriophages are abundant in the human body, including at sites of infection. We report that Pf4 phage, a filamentous bacteriophage produced by Pseudomonas aeruginosa , dampens inflammatory responses in response to either P. aeruginosa airway infection in a mouse model of acute pneumonia or bacterial endotoxin treatment. Pf4 triggers TLR3-dependent type I interferon production and antagonize production of anti-bacterial cytokines and chemokines. In particular, Pf4 phages inhibit CXCL5, preventing efficient neutrophil chemotaxis in response to endotoxin. These results suggest that Pf4 phages alter innate immunity to bacteria potentially dampening inflammation and neutrophil migration at sites of bacterial colonization or infection.
### Competing Interest Statement
The authors have declared no competing interest.
更多查看译文
关键词
bacteriophage,lung
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要