Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Yao Xiao, Zaijin Tao, Yufeng Ju,Xiaolu Huang,Xinshu Zhang, Xiaonan Liu, Pavel A. Volotovski, Chao Huang, Hongqi Chen,Yaozhong Zhang,Shen Liu

Nano-Micro Letters（2024）

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摘要

Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine. This study proposes the use of diamond-like carbon (DLC) deposited on polylactic acid (PLA) membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats. The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane, with histological score decreasing from 3.12 ± 0.27 to 2.20 ± 0.22 and anti-adhesion effectiveness increasing from 21.61

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关键词

Diamond-like carbon,Reactive oxygen species scavenging,Foreign body reaction,Biodegradation,Antioxidant,Peritendinous adhesion

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