Effect of Desulfation of Polysaccharides from Sea Urchin Eggs Paracentrotus Lividus on Antiproliferative Activity
Chemistry Africa(2024)
摘要
This study aims to study the impact of reducing the sulfate content and molecular weight of polysaccharides extracted from sea urchin eggs (Paracentrotus lividus) on antiproliferative activity against Caco-2 and B16 cell lines. Sulfated polysaccharides were initially extracted from sea urchin eggs, followed by a desulfation process. The characterization involved various techniques: Fourier-transform infrared spectroscopy for demonstrating desulfation, Gas Chromatography/Mass Spectrometry for determining monosaccharide composition, Size Exclusion Chromatography for confirming molecular weight reduction, and centesimal analysis for quantifying sulfate content. The initial molecular weight was 24,000 kg/mol decreased to 960 kg/mol, and sulfate content reduced from 9.41 to 1.31
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关键词
Paracentrotus lividus,Desulfated polysaccharides,Physico-chemical characterization,Antiproliferative activity
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