Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex

Mohamed A. Ghonim,Jihang Ju,Kusma Pyakurel,Salome V. Ibba, Mai M. Abouzeid,Hamada F. Rady,Shigemi Matsuyama,Luis Del Valle,A. Hamid Boulares

Journal of Inflammation（2024）

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摘要

The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is established, but its role in inflammation, as a complex or individual subunits, remains elusive. While only 1

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Inflammation,PRKDC,DNA repair,TNF-α,Phosphorylation

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