Nanomotif: Identification and Exploitation of DNA Methylation Motifs in Metagenomes using Oxford Nanopore Sequencing
biorxiv(2024)
摘要
DNA methylation is vital for understanding microbial biology, but a rarely used feature in recovery of metagenome-assembled genomes (MAGs). Recently, Oxford Nanopore introduced all context methylation detection models. We leveraged this to develop Nanomotif - a tool for identification of methylated motifs in metagenomic contigs. We demonstrate how this enables MAG contamination detection, association of mobile genetic elements, and linking of motifs with the responsible methyltransferase directly from Nanopore data.
### Competing Interest Statement
The authors have declared no competing interest.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要