Cumulative tenofovir exposure among patients with human immunodeficiency virus/hepatitis B co-infection with differential viral suppression.

Helen L Zhang,Meredith Mock,Lane Bushman,Peter L Anderson,Jennifer J Kiser,Susanna Naggie

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2024）

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摘要

This case-control study explored cumulative tenofovir exposure among patients with HIV/HBV co-infection with HIV viral suppression. Among patients taking tenofovir disoproxil fumarate, median TFV-DP levels in dried blood spots were ∼3-fold lower among patients with incomplete HBV viral suppression (n=4) compared to those with complete suppression (n=5) (516 vs.1456 fmol/punch).

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