Predictive value of CT and ¹⁸F-FDG PET/CT features on spread through air space in lung adenocarcinoma

Background Lung adenocarcinoma, a leading cause of cancer-related mortality, demands precise prognostic indicators for effective management. The presence of spread through air space (STAS) indicates adverse tumor behavior. However, comparative differences between F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography(PET)/computed tomography(CT) and CT in predicting STAS in lung adenocarcinoma remain inadequately explored. This retrospective study analyzes preoperative CT and F-18-FDG PET/CT features to predict STAS, aiming to identify key predictive factors and enhance clinical decision-making. Methods Between February 2022 and April 2023, 100 patients (108 lesions) who underwent surgery for clinical lung adenocarcinoma were enrolled. All these patients underwent F-18-FDG PET/CT, thin-section chest CT scan, and pathological biopsy. Univariate and multivariate logistic regression was used to analyze CT and F-18-FDG PET/CT image characteristics. Receiver operating characteristic curve analysis was performed to identify a cut-off value. Results Sixty lesions were positive for STAS, and 48 lesions were negative for STAS. The STAS-positive was frequently observed in acinar predominant. However, STAS-negative was frequently observed in minimally invasive adenocarcinoma. Univariable analysis results revealed that CT features (including nodule type, maximum tumor diameter, maximum solid component diameter, consolidation tumor ratio, pleural indentation, lobulation, spiculation) and all F-18-FDG PET/CT characteristics were statistically significant difference in STAS-positive and STAS-negative lesions. And multivariate logistic regression results showed that the maximum tumor diameter and SUVmax were the independent influencing factors of CT and F-18-FDG PET/CT in STAS, respectively. The area under the curve of maximum tumor diameter and SUVmax was 0.68 vs. 0.82. The cut-off value for maximum tumor diameter and SUVmax was 2.35 vs. 5.05 with a sensitivity of 50.0% vs. 68.3% and specificity of 81.2% vs. 87.5%, which showed that SUVmax was superior to the maximum tumor diameter. Conclusion The radiological features of SUVmax is the best model for predicting STAS in lung adenocarcinoma. These radiological features could predict STAS with excellent specificity but inferior sensitivity. Highlights center dot Evaluated PET/CT and CT features for predicting STAS in lung adenocarcinoma. center dot SUVmax and maximum tumor diameter were independent influential factors for STAS(+) in lung adenocarcinoma. center dot SUVmax showed higher predictive efficacy than maximum tumor diameter. center dot Radiological characteristics may serve as noninvasive biomarkers for STAS prediction in lung adenocarcinoma.