Highly Conjugated Nanozyme with Non Coordination Saturation for Cascaded Enhanced POD Reaction Driving Antibacterial Therapy

The misuse of antibiotics leads to emergence of drug-resistant bacteria. Developing artificial nanozymes with high stability and excellent catalytic performance is desirable to substitute for antibiotics, but still remains huge challenge. Herein, the study reports a new strategy for cascaded enhanced peroxidase (POD) reaction driving antibacterial therapy via constructing 2D conjugated metal-organic frameworks (MOFs) with non coordination saturation as nanozyme. It is demonstrated that the non coordination saturation Cu atom promotes the adsorption of H2O2, followed by the Cu-HHTP MOFs with high conjugated structure can enhance the photogenerated electron transfer for OH generation in POD reaction. The sequential enhancement of substrate adsorption and decomposition endows the as-made Cu-HHTP MOFs with outstanding antibacterial property of >99.9999% elimination with a concentration only 1/133 that of traditional nanozyme. In addition, the study also certifies its excellent in vivo antimicrobial activity and biocompatibility, indicating the therapeutic potential for infections by drug-resistant bacteria.