Alterations of electrocortical activity during hand movements induced by motor cortex glioma
arxiv(2024)
摘要
Glioma cells can reshape functional neuronal networks by hijacking neuronal
synapses, leading to partial or complete neurological dysfunction. These
mechanisms have been previously explored for language functions. However, the
impact of glioma on sensorimotor functions is still unknown. Therefore, we
recruited a control group of patients with unaffected motor cortex and a group
of patients with glioma-infiltrated motor cortex, and recorded high-density
electrocortical signals during finger movement tasks. The results showed that
glioma suppresses task-related synchronization in the high-gamma band and
reduces the power across all frequency bands. The resulting atypical motor
information transmission model with discrete signaling pathways and delayed
responses disrupts the stability of neuronal encoding patterns for finger
movement kinematics across various temporal-spatial scales. These findings
demonstrate that gliomas functionally invade neural circuits within the motor
cortex. This result advances our understanding of motor function processing in
chronic disease states, which is important to advance the surgical strategies
and neurorehabilitation approaches for patients with malignant gliomas.
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