CENTRAL AORTIC PRESSURE (CAP) MEASURED IN THE OFFICE WITH SPHYGMOCOR AND DURING 24 HOURS (MOBIL-O-GRAPH AND ARTERIOGRAPH) AND HYPERTENSION MEDIATED ORGAN DAMAGE (HMOD) IN YOUNG PAT

Objective: Central aortic pressure (CAP) is a parameter of central hemodynamics. It can be measured in the office with SphygmoCor, and during 24-hours with Mobil-O-Graph and Arteriograph. Debate is going on whether CAP is more associated with HMOD than brachial blood pressure. The aim of our study is to analyse assocation of office CAP and 24-hour CAP with HMOD in patients with stage 1 hypertension. Design and method: This study included 154 patients with the primary hypertension (69.5% women, mean age 38.5). In all of them we collected various clincial data and antroplogical paramaters. CAP was measured in the office (SphygmoCor) and during regular working days (24h ABPM systems: Mobil-o-Graph and Arteriograph). Results: The increased office CAP was associated with five indicators of HMOD: decrease in eGFR, increase in 24 hours albuminuria, thickness of the intima and carotid media (cIMT), NT pro-BNP, left ventricular hypertrophy- ECG Cornell criteria (LVH). Elevated 24-hour (Mobi-O-Graph) systolic CAP was associated with increased cITM and decreased EF. Higher values of diastolic CAP (Mobi-O-Graph) were accompanied by a greater possibility of LVH. An increase in 24 hours systolic CAP (Arteriograph) was followed with an increase in the cITM. An increase in 24 hours diastolic CAP(Arteriograph) was followed with a decrease in eGFR. Conclusions: CAP could be considered as a indicator of HMOD and total cardiovascular risk especially in young patients, but large longitudinal studies are need in order to confirm this. CAP measured with SphymoCor can be considered a better predictor of HMOD compared to CAP measured over 24 hours. Further investigation is needed to determine clinical value of both office and 24 hours CAP.