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Nanomolar Activity of Coumarin-3-thiosemicarbazones Targeting Trypanosoma Cruzi Cruzain and the T. Brucei Cathepsin L-like Protease

Jessica Alves Nunes,Paulo Fernando da Silva Santos-Junior, Midiane Correa Gomes, Luiz Alberto Santos Ferreira, Emanuelly Karla Araujo Padilha,Thaiz Rodrigues Teixeira, Emily J. Stanger, Yashpreet Kaur,Elany Barbosa da Silva,Clara Andrezza Crisostomo Bezerra Costa,Johnnatan Duarte de Freitas,Joao Xavier De Araujo-Junior,Francisco Jaime Bezerra Mendonca-Junior,Miriam A. Giardini,Jair L. Siqueira-Neto,Conor R. Caffrey,Peng Zhang,Silvia Helena Cardoso,Edeildo Ferreira da Silva-Junior

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2025）

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Key words
Carboxamides,Coumarines,Thiosemicarbazones,Trypanosoma,Multiscale QM/QM calculations
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