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个人简介
Our group combines computational and experimental techniques to study the cellular organization of complex tissues, with a focus on determining the phenotypic diversity and clinical significance of tumor cell subsets and their surrounding microenvironments. We have a particular interest in developing innovative data science tools that illuminate the cellular hierarchies and stromal elements that underlie tumor initiation, progression, and response to therapy. As part of this focus, we develop new algorithms to resolve cellular states and multicellular communities, tumor developmental hierarchies, and single-cell spatial relationships from genomic profiles of clinical biospecimens. Key results are further explored experimentally, both in our lab and through collaboration, with the goal of translating promising findings into the clinic.
研究兴趣
论文共 124 篇作者统计合作学者相似作者
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Aki Nakao,Aaron M. Newman,Ash A. Alizadeh, Maximilian Diehn, Mistuni Ghosh, Manjula Aliminati, Jayati Ghosh, Kristi Stephenson,Ashutosh Ashutosh
Cancer Researchno. 6_Supplement (2024): 4898-4898
Tej D Azad, Shigeki Nanjo,Michael C Jin, Jacob J Chabon, David M Kurtz, Aadel A Chaudhuri,Ian D Connolly, Angela Bik-Yu Hui,Chih Long Liu,David Merriott, Ryan Ko,Christopher Yoo,
NPJ precision oncologyno. 1 (2024): 121-121
Ajay Subramanian,Neda Nemat-Gorgani, Timothy J. Ellis-Caleo,David G. P. van IJzendoorn,Timothy J. Sears, Anish Somani,Bogdan A. Luca,Maggie Y. Zhou,Martina Bradic, Ileana A. Torres, Eniola Oladipo,Christin New,
Minji Kang,Jose Juan Almagro Armenteros,Gunsagar S. Gulati, Rachel Gleyzer, Susanna Avagyan, Erin L. Brown,Wubing Zhang,Abul Usmani,Noah Earland,Zhenqin Wu,James Zou,Ryan C. Fields,
bioRxiv the preprint server for biology (2024)
Cancer Discovery (2024)
Asiri Ediriwickrema,Yusuke Nakauchi,Amy C Fan, Thomas Köhnke, Xiaoyi Hu,Bogdan A Luca, YeEun Kim, Sreejith Ramakrishnan, Margaret Nakamoto,Daiki Karigane,Miles H Linde,Armon Azizi,
bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
CANCER CELLno. 11 (2023): 1989-+
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