基本信息
浏览量:9
职业迁徙
个人简介
Research in my laboratory focuses on functions of chemokines and chemokine receptors in primary and metastatic cancer. In particular, we are investigating independent and coordinated functions of chemokine CXCL12 (also known as SDF-1) and its two receptors, CXCR4 and CXCR7. These receptors are upregulated on malignant cells and tumor blood vessels in multiple malignancies, including breast and ovarian cancers, and CXCL12 also is secreted by stromal cells in primary and metastatic tumor microenvironments. Signaling through these receptors appears to regulate several steps in cancer initiation, progression, and metastasis.
To analyze these signaling pathways in cell-based assays and living mice, we utilize a wide variety of molecular imaging techniques ranging from intravital microscopy to whole animal imaging modalities. Through active collaborations with investigators in Biomedical Engineering (Dr. Shuichi Takayama) and Chemical Engineering (Dr. Jennifer Linderman), we develop novel microfluidic devices to study key steps in tumor progression under physiologic conditions in vitro and computational models to describe and predict signaling dynamics at multiple scales of biologic complexity. Our goals are to advance understanding of signaling pathways under physiologic conditions and gain new insights into mechanisms of metastasis that can be used to improve cancer therapy.
To analyze these signaling pathways in cell-based assays and living mice, we utilize a wide variety of molecular imaging techniques ranging from intravital microscopy to whole animal imaging modalities. Through active collaborations with investigators in Biomedical Engineering (Dr. Shuichi Takayama) and Chemical Engineering (Dr. Jennifer Linderman), we develop novel microfluidic devices to study key steps in tumor progression under physiologic conditions in vitro and computational models to describe and predict signaling dynamics at multiple scales of biologic complexity. Our goals are to advance understanding of signaling pathways under physiologic conditions and gain new insights into mechanisms of metastasis that can be used to improve cancer therapy.
研究兴趣
论文共 311 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
crossref(2024)
crossref(2024)
Patrick C. Kinnunen,Kenneth K. Y. Ho,Siddhartha Srivastava,Siddhartha Srivastava,Chengyang Huang,Wanggang Shen,Krishna Garikipati,Krishna Garikipati,Krishna Garikipati,Gary D. Luker,Gary D. Luker,Nikola Banovic, Xun Huan, Xun Huan,Jennifer J. Linderman,Jennifer J. Linderman,Kathryn E. Luker,Kathryn E. Luker
Frontiers in Systems Biology (2024)
crossref(2024)
crossref(2024)
crossref(2024)
Magnetic resonance in medicineno. 6 (2024): 2568-2578
crossref(2024)
Clinical cancer researchpp.OF1-OF12, (2024)
加载更多
作者统计
#Papers: 314
#Citation: 11329
H-Index: 50
G-Index: 101
Sociability: 7
Diversity: 0
Activity: 4
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn