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个人简介
I am a bioinformatics manager and computational researcher at IFOM ETS – The AIRC Institute of Molecular Oncology and my fields of research are Genetics, Bioinformatics, Oncology, Molecular Genetics and Precision Medicine. I have worked in the private and public sectors. I gathered excellent skills in Bioinformatics, Systems Biology, Oncology, Molecular Genetics and analysis of NGS data. I contributed to different projects: 1) Monitoring clonal evolution dynamics and the emerging of new resistant clone to therapy using liquid biopsy in CRC (Crisafulli et al., ESMO open 2019, Siravegna G, Lazzari L, Crisafulli G -- co-first author -- et al., Cancer Cell. 2018, Van Emburgh BO et al, Nat Commun. 2016) and breast cancer (Siravegna et al., ESMO open 2017), translating discoveries in clinics (Sartore-Bianchi et al. Nature Med 2022); 2) Understanding genetic processes such as adaptive mutability. Using NGS data of samples and cell models from CRC, we understood that cancer cells can adapt to therapeutic pressures by enhancing their mutability (Russo et al., Science 2019, Russo et al. Nat Genetics 2022); 3) Discovering a new biomarker to use in precision medicine: the number of mutations/neoantigens, linked to tumor load, can guide the therapy in colorectal cancer. High Tumor Load can improve immune surveillance and is required for effective immunotherapy response (Germano et al. Nature 2017, Pinocchino, Crisafulli et al. Cancers 2021, Merlini et al. Frontiers in Oncology 2022) and these results could be translated in clinics as shown in ARETHUSA clinical trial (Crisafulli et al. Cancer Discovery 2022).
研究兴趣
论文共 65 篇作者统计合作学者相似作者
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Molecular oncologyno. 6 (2024): 1460-1485
Briefings in bioinformaticsno. 4 (2024)
Cancer Researchno. 6_Supplement (2024): 5284-5284
FRONTIERS IN ONCOLOGY (2023): 1130852-1130852
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 22 (2023): 4530-4539
Mariangela Russo,Giulia Siravegna,Lawrence S. Blaszkowsky, Giorgio Corti,Giovanni Crisafulli,Leanne G. Ahronian, Benedetta Mussolin,Eunice L. Kwak, Michela Buscarino,Luca Lazzari, Emanuele Valtorta,Mauro Truini,
crossref(2023)
Francesca De Bacco,Francesca Orzan,Giovanni Crisafulli, Marta Prelli,Claudio Isella,Elena Casanova,Raffaella Albano,Gigliola Reato,Jessica Erriquez,Antonio D'Ambrosio,Mara Panero, Carmine Dall'Aglio,
CELL REPORTSno. 8 (2023): 112816-112816
CANCER RESEARCHno. 7 (2023)
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CANCER IMMUNOLOGY RESEARCHno. 12 (2023)
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