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个人简介
Dr. Okada is a creative physician-scientist who has developed therapeutic modalities in the laboratory, translated them into clinical protocols, and used his expertise as both scientist and clinician to assess the clinical data from ongoing trials. Dr. Okada's work has consistently focused on immunotherapeutic strategies aimed at a daunting challenge in oncology – malignant brain tumors. Dr. Okada conducted one of the first immune gene therapy trials in patients with malignant glioma. Dr. Okada's success in navigating the detailed regulatory processes that such trials require demonstrates his attention to detail and breadth of knowledge from basic science to clinical care. Dr. Okada's lab work was the first to identify and fully characterize cytotoxic T-lymphocyte (CTL) epitopes for gliomas. Dr. Okada's seminal discovery of CTL epitopes in glioma-associated antigens and the work on the mechanisms underlying the adjuvant effects of poly-ICLC enabled him to launch novel glioma vaccine trials in combination with poly-ICLC as an adjuvant. These efforts have also been supported by his mechanistic studies delineating the role of an integrin receptor very late activation antigen (VLA)-4 and chemokine CXCL10 in efficient trafficking of T-cells to brain tumor sites. Dr. Okada has held 4 Investigational New Drug approvals for his own vaccine trials
研究兴趣
论文共 430 篇作者统计合作学者相似作者
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EBIOMEDICINE (2024): 104963-104963
Marco Gallus,Victor Andres Arrieta,Atsuro Saijo,Pavlina Chuntova,Akane Yamamichi, Jeffrey Haegelin, Su Phyu, Lan Phung, Shayan A. Amir-Kabirian,Senthilnath Lakshmanachetty,Li Chen,Karl Habashy,
Cancer Researchno. 6_Supplement (2024): 6648-6648
Journal of clinical oncology : official journal of the American Society of Clinical Oncologypp.JCO2302195-JCO2302195, (2024)
Neuro-oncologyno. 2 (2024): 335-347
Mark Gilbert, Wei Zhang,Hideho Okada,Masaki Terabe,Gary Kohanbash,Hua Song,Dionne Davis,James McAuliffe,Laurine Noblecourt, Emily E Steffke, Taijun Hana, Laila Latifi,
Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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