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个人简介
Weissman and his lab are investigating protein folding and probe the mysteries behind the organizational principles of biological systems through a variety of molecular and technological methods. While technologies like RNA-seq have made it much easier to monitor which genes are being expressed in a cell at any given time, these approaches use messenger RNA as a proxy for proteins. But generally it is proteins, and not RNAs, that mediate a gene’s cellular functions. That means RNA sequencing is an imperfect indicator for what is actually going on in a cell. To address this issue, Weissman developed a method called ribosome profiling, which measures the ribosomes active in a cell -- and the mRNA, soon to become proteins, inside them.
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Nature reviews. Molecular cell biologypp.1-1, (2024)
Haley Halasz,Eric Malekos,Sergio Covarrubias, Samira Yitiz, Christy Montano,Lisa Sudek,Sol Katzman,S John Liu,Max A Horlbeck, Leila Namvar,Jonathan S Weissman,Susan Carpenter
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2024): e2322524121-e2322524121
bioRxiv : the preprint server for biologyno. 6 (2024): 1101-1119.e9
Arnav Mehta,Lynn Bi, Deepika Yeramosu, Michael Bogaev, Martin Jankowiak, Abigail Collins, Aziz Al'Khafaji, Milan Parikh, Mehrtash Babadi, Kyle Evans,Alex Bloemendal, Russell Kunnes,
Cancer Researchno. 7_Supplement (2024)
Chen Weng, Fulong Yu,Dian Yang,Michael Poeschla,L Alexander Liggett, Matthew G Jones,Xiaojie Qiu,Lara Wahlster,Alexis Caulier, Jeffrey A Hussmann,Alexandra Schnell, Kathryn E Yost,
Brian T Do,Peggy P Hsu, Sidney Y Vermeulen, Zhishan Wang,Taghreed Hirz,Keene L Abbott,Najihah Aziz,Joseph M Replogle,Stefan Bjelosevic, Jonathan Paolino, Samantha A Nelson,Samuel Block,
Developmental cell (2024)
Shruti Menon,Marcus R Breese, Yone Phar Lin,Hannah Allegakoen, Shruthi Perati,Ann Heslin,Max A Horlbeck, Jonathan Weissman,E Alejandro Sweet-Cordero,Trever G Bivona,Asmin Tulpule
Research square (2023)
Cellno. 14 (2023): 2977-2994.e23
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