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Ten Feizi’s research started on the red cell autoantibodies triggered by Mycoplasma pneumoniae infection. She established that the autoantibodies (known as anti-I) are mono- or oligo-clonal and directed at carbohydrate sequences (glycans) that are backbones of the blood group antigens ABO(H) and also of the host cell attachment sites of M. pneumoniae providing an explanation for their immunogenicity when complexed with the infective agent serving as an adjuvant. Her laboratory was also the first to sequence the glycans of the envelope glycoprotein gp120 of HIV and demonstrate their interactions with the macrophage receptor. This glycoprotein, which plays a crucial role in how the virus evades the immune system, remains an important target for the development of potential HIV vaccines.
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Journal of Reproductive Immunology (2023): 104083-37
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022): 55-56
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Ingrida Vendele,Ten Feizi, Maria Spyrou,Mark Stappers,Gordon Brown,Janet Willment,Lisete Silva,Angelina Palma, Wengang Chaie,Yan Liu,Neil Gow
Access Microbiologyno. 12 (2021)
FEBS Lettersno. 23 (2018): 3976-3991
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