Beckomberga Hospital (Swedish: Beckomberga sjukhus) was a Swedish psychiatric hospital, situated in Bromma west of Stockholm. Opened in 1932, Beckomberga was in its mid-20th century heyday one of the largest psychiatric hospitals in Europe, housing some 2,000 mentally ill patients. The hospital was closed in 1995..
ABSTRACT— Eighty‐three acutely disturbed, psychotic patients were included in an open multicentre study. The aim of the study was to evaluate the clinical effect of zuclopenthixol acetate in Viscoleo® (CPT‐A). Each patient received from one to four intramuscular injections of CPT‐A during the 6‐day study period. The duration of action after one injection was between 2 and 3 days and doses from 50 mg to 150 mg were sufficient for most patients.Treatment with CPT‐A caused a pronounced and rapid reduction of the psychotic symptoms. At the end of the 6‐day test period the mean total score on BPRS in acute non‐manic and exacerbated chronic patients was reduced by more than 50 per cent. In acute manic patients the mean total score on BRMS was reduced by 57 per cent already 1 day after injection. Rapidly after the injection of CPT‐A a useful short‐acting sedation can be expected, but the risk for oversedation even after a second injection is low. The frequency of unwanted effects, including extrapyramidal reactions, was low and the severity of symptoms was most often mild. With a rapid onset of action, a duration of effect of 2 to 3 days, and few and mild side effects, CPT‐A offers advantages over the neuroleptic preparations conventionally used in the initial treatment of acutely disturbed, psychotic patients.
Conference Abstract| April 01 1973 Energy Metabolism in Human Muscle Eric Hultman Eric Hultman 1Department of Clinical Chemistry, Beckomberga Sjukhus, 161 04 Bromma, Sweden Search for other works by this author on: This Site PubMed Google Scholar Clin Sci Mol Med (1973) 44 (4): 12P–13P. https://doi.org/10.1042/cs044012Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Eric Hultman; Energy Metabolism in Human Muscle. Clin Sci Mol Med 1 April 1973; 44 (4): 12P–13P. doi: https://doi.org/10.1042/cs044012Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1973 The Biochemical Society and the Medical Research Society1973 Article PDF first page preview Close Modal You do not currently have access to this content.
Concentrations of the major monoamine metabolites homovanillic acid (HVA) 4-hydroxy-3-methoxyphenylethylene glycol (MOPEG), and 5-hydroxyindoleacetic acid (5-HIAA) were determined in lumbar CSF of psychotic women with a schizophrenic symptomatology before and 4 weeks after treatment with sulpiride (Dogmatil 200 mg×4). The metabolites were determined by a mass fragmentographic method. Prolactin concentrations in CSF and plasma were determined by radioimmunoassay. The clinical effects were evaluated by ratings according to the comprehensive psychopathology rating scale (CPRS) and a scale for side effects. Levels of HVA and prolactin in CSF and plasma were significantly elevated during treatment. No effects on concentrations of MOPEG or 5-HIAA were observed. The biochemical data indicate that clinical doses of sulpiride blocked dopamine receptors in the nigrostriatal pathway as well as in the tuberoinfundibular system. Treatment with sulpiride was associated with marked reductions in psychotic morbidity.
The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG. Levels of HVA, 5-HIAA, prolactin, or total protein in CSF were not significantly influenced by treatment. The results indicate a specific alteration of central noradrenaline metabolism in relation to ECT.
