The Chitose Institute of Science and Technology (公立千歳科学技術大学, Koritsu Chitose Kagaku Gijutsu Daigaku) is a technical university in Chitose, Hokkaido, Japan. It was established in 1998.
Dietary flavonoids associate with disease prevention in epidemiological studies, yet their polypharmacological mechanisms remain unclear. We establish network pharmacology as a systematic framework to characterize flavonoid therapeutic properties through integrated computational, experimental, and epidemiological validation. We constructed a master network of 17,869 human proteins, 14 dietary flavonoids, and 1,496 FDA-approved drugs with 278,768 interactions. Flavonoids averaged 45.3 target proteins per compound compared to 16.8 for FDA-approved drugs (2.7-fold higher; p=7.5x10^-4), reflecting multi-target architecture. Statistical analysis revealed that 71.4
This paper reports on the design and implementation of a short-term STEAM education program for smart agriculture. We invited two faculty members and three undergraduate students from the Institute of Technology of Cambodia and conducted intensive training that integrated image electronic engineering and agricultural engineering. The program consisted of three modules: LED matrix control for agricultural signage, three-dimensional plant measurement using an RGB-D camera, and water quality monitoring in an IoT-based aquaponics system. Undergraduate and graduate students at our university designed and delivered the classes in English. Through project-based group work, participants gained hands-on experience with core technologies for agricultural DX and developed international communication skills.
Homopropargyl alcohols are versatile building blocks in a wide range of synthetic transformations; consequently, the development of efficient and practical methods for their preparation remains an important objective in organic synthesis. This study presents a novel and practical zinc iodide mediated three‐component reaction of terminal alkyne‐bearing propargyl carbamates, trialkylboranes, and aldehydes for the synthesis of homopropargyl alcohols. A variety of α,γ‐substituted allenylboranes are formed in situ through a 1,2‐metallate shift of alkynylborates to the sp carbon atom, which subsequently react with aldehydes to afford the corresponding homopropargyl alcohols. In contrast to conventional methods for the generation of alkynylborates, the present system requires only a catalytic amount of lithium diisopropylamide as the base.
1,2,4-Trisubstituted chiral homoallylic alcohols are valuable intermediates in natural product synthesis and complex molecular architectures; however, their catalytic asymmetric synthesis remains challenging due to the need for precise control of regioselectivity, diastereoselectivity, E/Z geometry, and enantioselectivity. Herein, we report a palladium-catalyzed enantiospecific three-component reaction of aldehydes, borylated allyl acetates, and dimethylzinc for the efficient synthesis of 1,2,4-trisubstituted anti-(Z)-homoallylic alcohols. The present method employs readily accessible chiral borylated allyl acetates and proceeds with high levels of stereochemical control, providing a practical approach to structurally complex homoallylic alcohols.
