Chung Shan Medical University Hospital is affiliated with the university..
To evaluate the efficiency, predictability, and residual astigmatism between first- and second-generation keratorefractive lenticule extraction (KLEx) surgeries in a prominent astigmatism population. A retrospective cohort study was conducted, and individuals who underwent first- and second-generation KLEx surgeries were enrolled. A total of 31 and 35 eyes were categorized into first and second KLEx groups, respectively. Visual acuity, refraction, topographic parameters, and surgical indices were recorded. Independent t tests were used to compare the postoperative uncorrected distance visual acuity (UDVA), spherical equivalent (SE), and residual astigmatism between the two groups. The difference in UDVA was not significant three months after KLEx surgery (P = 0.509), and the SEs three months after surgery also presented similar values between the two groups (P = 0.552). The first KLEx group demonstrated greater residual astigmatism than did the second KLEx group throughout the three-month follow-up period (all P < 0.05). The values of surgically induced astigmatism (SIA), difference vector (DV), magnitude of error (ME) and correction index (CoI) were significantly better in the second KLEx group via vector analysis (all P < 0.05). Old age, high steep keratometry (K), high topographic cylinder, large angle kappa, and a small optic zone were correlated with greater residual astigmatism in the first KLEx group (all P < 0.05), whereas only a small optic zone was significantly correlated with greater residual astigmatism in the second KLEx group (P = 0.047). The second-generation KLEx is correlated with a lower risk of residual astigmatism.
In this study, we synthesized (E)-N'-(4-methoxybenzylidene)-2-((5-phenyl-1H-pyrazol-3-yl)oxy)acetohydrazide (MBPA), a novel compound exhibiting significant inhibitory activity against alpha-amylase and alpha-glucosidase enzymes. The target compound was obtained through a condensation reaction between 2-((5-phenyl-1H-pyrazol-3-yl)oxy)acetohydrazide and 4-methoxybenzaldehyde. Structural confirmation was achieved using comprehensive spectroscopic techniques, including 1H NMR, 13C NMR, FT-IR, and HRMS-ESI. Additionally, single-crystal X-ray diffraction (XRD) analysis was performed to elucidate the molecular structure. The molecular geometry, electronic properties, and reactivity descriptors of the compound were investigated using density functional theory (DFT) at the B3LYP/6-311++G(d,p) level. Key analyses included MEP, NBO, QTAIM, and NCI. Additionally, Hirshfeld surface analysis was employed to characterize intermolecular interactions within the MBPA crystal structure, utilizing normalized contact distance (dnorm) surfaces and 2D fingerprint plots. MBPA was evaluated for its antihyperglycemic potential through in vitro assays. The compound demonstrated significant inhibitory effects against both alpha-glucosidase (IC50 = 68.99 +/- 0.85 mu M) and alpha-amylase (IC50 = 174.1 +/- 1.85 mu M), outperforming the standard drug acarbose (IC50 values of 98.12 +/- 2.10 mu M and 126.5 +/- 2.10 mu M, respectively). In addition, molecular docking studies were performed to investigate the interaction between the ligand (MBPA) and receptor proteins, alpha-glucosidase (PDB code: 3W37) and alpha-amylase (PDB code: 3CPU).
PURPOSE:This study investigates the psychological determinants of healthcare professionals' support for green hospital transitions by integrating the values-attitude-behavior (VAB) framework with the Theory of Planned Behavior. DESIGN/METHODOLOGY/APPROACH:A survey of 300 Taiwanese healthcare employees was conducted, and the data were analyzed using Covariance-Based Structural Equation Modeling. FINDINGS:Green values (GV) had a significant positive influence on attitudes, subjective norms (SN), and perceived behavioral control (PBC). However, GV did not directly influence behavioral intention. Among the theory constructs, only PBC had a significant positive effect on behavioral intentions (BI). Attitudes and SN did not have significant impacts. Furthermore, government policy (GP) demonstrated a significant positive direct effect on BI, however, analysis found no significant moderating effects on the relationships between attitude, subjective norm, PBC and intention. RESEARCH LIMITATIONS/IMPLICATIONS:The study focused on healthcare workers in Taiwan, future research should include more diverse populations or conduct comparative studies across various regions. PRACTICAL IMPLICATIONS:Hospital managers should prioritize training and resource provision to enhance staff control over environmental practices, while policymakers should maintain clear regulations and incentives to accelerate progress toward carbon-neutral healthcare. SOCIAL IMPLICATIONS:The findings of this study have significant implications for the development of sustainable healthcare practices and the achievement of sustainable development goals. ORIGINALITY/VALUE:Originality lies in the study's integrated VAB-TPB framework, which is uniquely applied to the high-constraint healthcare environment, offering a more nuanced model than prior single-theory applications. This study differs by demonstrating the primacy of PBC over attitudes and norms in a professional context and identifying GP as a direct driver rather than a moderator of intention. Focusing on Taiwan provides a distinctive case study of a high-performing healthcare system facing an urgent, policy-driven sustainability transition, strengthening the study's contribution to the green healthcare field.
BACKGROUND/AIM:Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has been linked to antioxidant, anti-inflammatory, and vasoprotective effects. Yet, evidence from randomized controlled trials (RCTs) remains inconsistent, and the quality, dosage, and cost of commercial resveratrol products vary considerably, raising uncertainty about their true efficacy. A comprehensive synthesis of its effects on obesity-related non-communicable diseases (NCDs) is therefore warranted. Given that obesity is a key driver of metabolic dysregulation underlying diabetes, cardiovascular disease, and fatty liver disease, clarifying resveratrol's potential in overweight and obese populations is of particular importance. MATERIALS AND METHODS:We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science for RCTs published up to July 2025 that evaluated resveratrol supplementation in adults with obesity-related metabolic disorders or associated risk factors. Study selection and data extraction followed PRISMA 2020 guidelines. Pooled estimates were calculated using random-effects models, and heterogeneity was assessed with the I2 statistic. RESULTS:Forty RCTs involving 2551 participants were included. Resveratrol significantly reduced the homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol, systolic blood pressure (SBP) and diastolic blood pressure (DBP), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). No consistent changes were observed for high-density lipoprotein (HDL) cholesterol, body weight (BW), body mass index (BMI), fat mass, hip circumference (BC), waist circumference (WC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), or liver fat. To our knowledge, this meta-analysis includes the largest number of RCTs to date and the most comprehensive coverage of obesity-related metabolic and inflammatory endpoints. Effect sizes varied by intervention dose and duration. CONCLUSION:Resveratrol supplementation shows modest benefits on selected metabolic and inflammatory parameters but does not exert broad effects across all obesity-related NCD risk factors. Its potential role may be most relevant in populations with metabolic disturbances. Large-scale, long-term RCTs are warranted to clarify optimal dosing strategies and establish its utility in the prevention and management of obesity-related non-communicable diseases.
Dermal fibroblasts are pivotal in maintaining skin integrity through extracellular matrix (ECM) production, a process compromised during aging due to oxidative stress from excessive reactive oxygen species (ROS). Salvia miltiorrhiza Bunge (Danshen, DS), a medicinal plant rich in bioactive compound-rich dried roots, has demonstrated broad therapeutic potential. This study investigates the anti-aging properties of Danshen callus (DSC)-an undifferentiated cell mass derived from leaf tissue culture, as a sustainable and controlled source of bioactive compounds. Using hydrogen peroxide (H2O2)-induced premature aging and chronological aging models in human dermal fibroblasts (HDFs), we evaluated DSC effects on redox homeostasis and senescence. Pretreatment and posttreatment with DSC significantly enhanced HDF viability, restored ECM synthesis, suppressed MMP-1 secretion, and reduced senescence-associated markers in H2O2-induced premature aging HDFs. Mechanistically, DSC activated the Nrf2/ARE pathway, mitigating ROS accumulation and reinforcing antioxidant defenses. Crucially, comparative analysis revealed DSC superior efficacy over native Danshen (DS) in both aging paradigms. These findings highlight DSC potential as a novel, plant-based therapeutic agent for anti-aging cosmetic formulations, leveraging agricultural waste for sustainable skincare solutions.
