Jaffna Teaching Hospital

BACKGROUND:Blood-pressure reduction is the only proven treatment to prevent stroke. Whether a single pill that combines three antihypertensive drugs at low doses, in addition to standard antihypertensive treatment, can lower blood pressure more than standard care alone and reduce the risk of recurrent stroke after intracerebral hemorrhage is uncertain. METHODS:We conducted a multinational, double-blind, randomized, placebo-controlled trial involving patients with a history of intracerebral hemorrhage. Patients were eligible for the trial if they had a systolic blood pressure of 130 to 160 mm Hg at baseline and were in clinically stable condition. After a 2-week active run-in phase during which all the patients received a once-daily pill containing three antihypertensive agents at low doses (telmisartan at 20 mg, amlodipine at 2.5 mg, and indapamide at 1.25 mg; the triple pill), the patients were randomly assigned to continue receiving the triple pill or to receive matching placebo. The primary outcome was the first recurrent stroke. Secondary outcomes included blood-pressure control, major cardiovascular events, death from cardiovascular causes, and safety. RESULTS:Of 1670 patients who underwent randomization, 833 were assigned to receive the triple pill and 837 to receive placebo. The mean age of the patients was 58 years. At a median follow-up of 2.5 years, recurrent stroke had occurred in 38 patients (4.6%) in the triple-pill group and 62 (7.4%) in the placebo group (hazard ratio, 0.61; 95% confidence interval [CI], 0.41 to 0.92; P = 0.02). The mean systolic blood pressure during follow-up was 127 mm Hg and 138 mm Hg, respectively. The incidence of major cardiovascular events was lower with the triple pill than with placebo (6.6% vs. 9.8%; P = 0.04). Serious adverse events occurred in 23.2% of the patients in the triple-pill group and 26.0% of those in the placebo group. Early discontinuation of the trial regimen due to an adverse event occurred in 13.6% and 6.0%, respectively. The most common adverse event leading to discontinuation was an increase of 20% or more in the serum creatinine level. CONCLUSIONS:Among patients with intracerebral hemorrhage, treatment with a combination of three low-dose antihypertensive agents in a single pill, in addition to standard care, was associated with a lower incidence of recurrent stroke and major cardiovascular events than placebo. (Funded by the National Health and Medical Research Council of Australia and the Brazilian Ministry of Health; TRIDENT ClinicalTrials.gov number, NCT02699645; Australian New Zealand Clinical Trials Registry number, ACTRN12616000327482.).

Introduction: Rugby is a physically demanding full-contact team sport that carries a high risk of musculoskeletal injuries during both match play and training. Knee injuries are among the most typical injuries reported by rugby players globally, accounting for the largest percentage of practice and game days lost (21%), yet there is no data on knee injuries among Sri Lankan school-level rugby players.Methods: A descriptive cross-sectional study with analytical components was conducted from 1st of October 2025 to 31st of January 2026. The study population comprised all Under-19 A-Division school rugby players from ten Colombo District schools.Results: Knee injuries recorded 149 (47.0%). The most frequent injury types were meniscal tears (34.9%), collateral ligament sprains (24.2%) and anterior cruciate ligament (ACL) sprains (16.8%). The right knee was most commonly affected (74.5%), and the majority of injuries occurred during the second half of match play (59.1%), predominantly through tackling (33.6%). BMI category showed a statistically significant association with knee injury occurrence (p=0.02), with obese class II players at the highest risk. Playing position, age group, playing experience, and preferred kicking leg were not significantly associated with injury occurrence. All injured players experienced absence from training or matches and from school, both of which are highly significant.Conclusions: Knee injuries are common within Under-19 A-Division school rugby players in the Colombo District, causing a significant impact on athletic performance and academic performance. Elevated BMI and the tackling phase are important modifiable targets for prevention. A national prospective injury surveillance system and evidence-based knee injury prevention programs are urgently needed for school-level rugby in Sri Lanka.

Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality when ultrasound is inconclusive. This study evaluates the visibility and anatomical characteristics of a normal appendix using NCCT. Methods This retrospective descriptive study was conducted in the Radiology Unit of Teaching Hospital Jaffna, in Jaffna, Sri Lanka, from September 2023 to February 2024, following approval from the Institutional Ethical Review Committee of the hospital. Two hundred individuals were evaluated (past appendectomy patients were excluded). IBM SPSS Statistics software, version 26 (IBM Corp., Armonk, NY, USA) was used, with significance assessed at P ≤ 0.05.  Results Males were 64.5%. The visibility rate was 89%. The most common positions were retrocecal (27.5%), retroileal (22%), and pelvic (21.5%). The mean length was 7.5 cm, with a base diameter of 6.6 mm, a mid-section of 6.2 mm, and a tip of 5.8 mm. Mean wall thickness was 2.6 mm, fecoliths were found in 15% of cases, and the mean distance of the base from McBurney's point was 3.32 cm. Conclusion NCCT can be used to assess the morphology, position, and presence of fecolith in equivocal cases of suspected appendicitis when ultrasound is inconclusive and contrast is contraindicated. The appendicular diameter and wall thickness can be used as evidence of inflammation. McBurney's point is a reliable anatomical guide during open appendicectomies. The presence of a fecalith itself is not a reliable indicator of appendicitis.

T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that frequently presents with mediastinal masses, lymphadenopathy, or bone marrow failure. Presentation with cardiac tamponade due to pericardial effusion is uncommon and can be life-threatening. We report a 19-year-old man with no previously known medical illness, who presented with progressive exertional dyspnoea, pleuritic chest pain, orthopnoea, and dysphagia of one week duration. Clinical and imaging findings revealed massive pericardial effusion with impending tamponade, necessitating urgent pericardiocentesis. Laboratory evaluation showed marked leucocytosis with lymphocytic predominance and thrombocytopenia. Bone marrow biopsy and flow cytometry confirmed the diagnosis of T-ALL. This case highlights the importance of considering haematological malignancy in young patients presenting with pericardial effusion and emphasises the need for prompt recognition and multidisciplinary management to prevent fatal outcomes.

INTRODUCTION:Early diagnosis and treatment of atrial fibrillation (AF) are crucial to reduce AF-related complications and associated healthcare costs. In low-resource settings, digital health technologies could help achieve this; however, costs of different screening strategies are key for policy change. METHODS:This decision-tree model representing the Sri Lankan public health system perspective used prevalence data from a community-based cross-sectional study of 10 000 individuals aged ≥50 years in Northern Province, Sri Lanka. Participants were screened for AF using AliveCor, a handheld single-lead ECG device. Three screening strategies (systematic, opportunistic and targeted) were compared against each other. The incremental cost-effectiveness ratio (ICER) is presented, representing the incremental total aggregated cost between screening strategies divided by the incremental number of new detected AF cases to generate a cost per additional new AF cases detected for a 1-year time horizon. RESULTS:Systematic screening detected 48 new AF cases, and the targeted screening detected 47. Systematic screening was more expensive (Sri Lankan rupees (Rs) 698 422; US$2123) for 10 000 screened individuals compared with targeted screening (Rs 492 002; US$1496) for 7780 screened individuals. Opportunistic screening was the cheapest strategy (Rs 360 617; US$1096) for screening 6556 individuals; however, only 30 new AF cases were identified. The ICER of targeted screening was lower compared with opportunistic screening (Rs 7729; US$23 per additional detected AF case) whereas the ICER of systematic screening compared with opportunistic screening was higher at Rs 18 767 (US$57) per detected AF case. When the systematic screening strategy was compared with targeted screening, the cost per additional detected AF case increased to Rs 206 420 ($628). CONCLUSION:Targeted screening with AliveCor was the most cost-effective strategy. Systematic screening, while having similar effectiveness, was not cost-effective due to the high additional costs to detect just one further case. These findings support integrating targeted screening into Sri Lanka's primary care pathways.