The Khulna Medical College (KMC) (Bengali: খুলনা মেডিকেল কলেজ) is a government medical school in Khulna, Bangladesh. It is affiliated with Sheikh Hasina Medical University. It is located in the city of Khulna, near the inter-district Bus Stand at the entrance to the city.Khulna Medical College was established in 1992. The current principal is Md Abdul Ahad.
Non-alcoholic fatty liver disease (NAFLD) and type 2 Diabetes Mellitus are the major causes of significant mortality and morbidity. NAFLD and type 2 diabetes have common risk factors. SGLT-2 inhibitors are believed to have a beneficial effect on liver fat in patients with NAFLD and type 2 diabetes. However, there are limited data available on this aspect of empagliflozin use. Thus, we aimed to compare the impact of empagliflozin on liver fat reduction in type 2 diabetes and NAFLD. A comprehensive search of databases like PubMed, Google Scholar, and Cochrane Library was done. In the end, a detailed analysis was performed on a total of 6 finalized studies, all of which were randomized controlled trials. This comprehensive analysis consisted of a cohort of 589 Individuals. A total of six studies were included. Primary outcomes assessed were MRI-PDFF, AST, ALT, HOMA-IR and total bilirubin. Empagliflozin significantly reduced liver fat compared to placebo, with a pooled standardized mean difference (SMD) of −0.43 (95
A bstract Background: Effects of meal- and sleep-related factors on glucometabolic control among South-Asian people with type 2 diabetes mellitus (T2DM) were inadequately reported, especially in the context of sex. Objective: This study evaluated the sex-specific associations of meal- and sleep-related factors on glucometabolic control among people with T2DM. Materials and Methods: From February to December 2025, we enrolled 694 adults with T2DM across four hospitals. Data collection included meal- and sleep-related histories, physical measurements (height, weight, waist circumference, and blood pressure [BP]), and glucometabolic parameters (e.g., glycated hemoglobin, plasma glucose, fasting lipid profiles, and body indices). Findings were categorized and evaluated against established clinical recommendations to identify abnormal health values. Results: Obesity and dyslipidemia were more frequent in females compared with males. More than three daily meals were associated with higher odds for hypertriglyceridemia (odds ratio [OR] = 2.0) in males but lower odds for low high-density lipoprotein-cholesterol (OR = 0.4) in females. Bedtime after 11 pm was associated with higher odds for general (OR = 2.1) and central obesity (OR = 1.9) only in males. Dinner–bedtime interval up to 2 h was associated with higher odds for high total cholesterol (TC), both for males (OR = 2.4) and females (OR = 1.8), and uncontrolled systolic BP (OR = 1.7) in females. Sleep duration at night below 6 h was associated with higher odds for uncontrolled diastolic BP (OR = 2.8) and overall uncontrolled BP (OR = 2.5) in males, and higher odds for high TC (OR = 1.7) in females. Conclusion: Meal- and sleep-related factors may be associated with poor glucometabolic status with distinctive sex-specific association in people with T2DM.
Cardiac amyloidosis is underdiagonosed under diagnosed and can cause progressive heart failure. This results in progressive ventricular stiffening, loss of diastolic filling, arrhythmias, and eventually heart failure. Early diagnosis is important because newer disease-modifying therapies and optimized heart failure management can lead to better outcomes for the patient. A 50-year-old Bangladeshi female with a new diagnosis of type-2 diabetes mellitus reported a six-month history of progressive shortness of breath with exertion that was currently NYHA class III. She also complained of occasional paroxysmal nocturnal dyspnea, chronic dry cough, generalized swelling and unintentional weight loss. No pallor or jaundice. Pulse rate 88 beat/min, blood pressure 102/64 mmHg, respiration rate 16 breath/min, bibasilar crackles on lung auscultation, shifting dullness, ascites perhaps, tender hepatomegaly. There were no other abnormal systemic findings. In such scenarios, where endomyocardial biopsy and modern genetic analysis are not feasible, clinical acumen and traditional non-invasive imaging features (like echocardiographic apical sparing and cardiac MRI late gadolinium enhancement) will play a crucial role in early diagnosis. One important lesson is that conventional heart failure treatment regimens should be used with great caution in restrictive cardiomyopathies, and easily accessible disease-specific therapies are needed.
N-acetylcysteine (NAC) is becoming more and more popular medication in the management of mental health conditions. NAC antiinflammatory, antioxidant and glutamate transmission properties, currently being explored for the therapeutic intervention of neurological conditions, e.g. anxiety, depressive disorders, post-traumatic stress disorder, obsessive-compulsive disorders, bipolar disorders and schizophrenia. Clinical studies for many psychiatric diseases have yielded contradictory findings, despite the fact that there is a wealth of preliminary data and intellectual support for the application of NAC in the treatments of many of these illnesses. The most of the research studies have proven insufficient and too briefly explored. More research are required to established NAC efficacy, appropriate indication and adverse drug reactions.
