Link Campus University (Italian: Università degli studi Link Campus University), formerly Link Campus—University of Malta, is a proprietary, for-profit university located in Rome, Italy, and owned by the for-profit Italian franchise chain CEPU. The university is associated with Italian intelligence agencies.
The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.
Cellular senescence arises through replicative exhaustion or acute stress, yet whether these distinct triggers share a reproducible transcriptional organization has remained unresolved. Seven public human fibroblast RNA-seq datasets were integrated across both trigger types, moving from differential expression through Gene Ontology and Reactome enrichment to protein-protein interaction network embedding within a single harmonized framework. Both triggers converged on concordant repression of replication and chromatin programs alongside induction of inflammatory and extracellular matrix outputs. Cross-trigger combination identified 263 commonly repressed and 112 commonly induced GO terms, with consistently higher enrichment scores in the repressed set, and 145 versus 13 shared Reactome pathways. Conserved induction of calcium ion homeostasis and membrane potential regulation, and conserved repression of RHO GTPase-Formin signaling, extended the shared program beyond canonical SASP biology into dimensions not previously described in human fibroblasts. Interactome embedding, applied here for the first time in a cross-trigger senescence framework, identified ten genes occupying both induced and repressed neighborhoods simultaneously, a structural layer invisible to enrichment analysis alone. ELAVL1 coordinates SASP output and growth arrest post-transcriptionally, while suppressed PARP1 alongside active ATM defines a self-reinforcing damage configuration. These results provide a quantitative cross-study reference and a structured basis for senotherapeutic candidate prioritization.
Understanding how relationships among global financial markets change over time is crucial for effective risk management, portfolio diversification, and risk assessment. Motivated by the recent episodes of market turmoil, in this paper we analyse daily returns for 21 major indices covering cryptocurrencies, equities, energy commodities, and exchange rates from 2017 to 2025 by developing a novel time-varying graphical model for detecting the evolution of conditional dependency structures in financial markets. To identify temporal shifts in market regimes and account for the characteristics of returns, we exploit nonparanormal distributions with state-dependent parameters that evolve according to a latent finite-state semi-Markov chain. Our methodology results in regime-specific graphs that capture dynamic network connectivity while preserving the tractability of Gaussian methods for identifying conditional dependencies. Model estimation is carried out with a penalized Expectation-Maximization algorithm to induce sparsity in the state-specific precision matrices, without parametric assumptions about the states' sojourn distributions.
To evaluate 36-month clinical outcome and occurrence of sealer apical extrusion events of teeth obturated with a premixed CaSi based sealer associated with a single cone technique or carrier-based technique. In this retrospective cohort study, consecutive healthy patients were treated by a postgraduate master cohort. Teeth were shaped with NiTi rotary or reciprocating instruments, irrigated with 5
Gastric bleeding is a major symptom of locally advanced gastric cancer and a significant cause of mortality. Management options include surgery, endoscopic interventions, embolization and radiotherapy (RT). Although palliative RT appears effective for hemorrhage control, evidences are limited to underpowered retrospective studies from Asia, with issues of patient heterogeneity and response evaluation criteria. This study is a multicenter retrospective analysis carried out across Italian radiation oncology centers to evaluate real-world outcomes of hemostatic RT in patients with bleeding gastric cancer. Clinical and dosimetric data were retrospectively collected for patients with active bleeding gastric cancer treated across twelve Italian radiation oncology centers. The primary endpoint was to evaluate hemoglobin stabilization or improvement at four weeks post-treatment. Secondary outcomes included treatment parameters, acute toxicity profile and time to rebleeding. Between January 2018 and October 2024, 100 patients receiving hemostatic RT were collected for the analysis. The median age was 77 years, 68
